Τhe two main determinants of cardiovascular phenotype in haemoglobinopathy patients are the underlying molecular defect
responsible for the main disease and the therapy applied for its management. The spectrum of cardiovascular manifestations in
haemoglobinopathies is wide and includes ventricular dysfunction, pulmonary hypertension, thromboembolic events. We report
a case of thalassemia and one of sickle cell disease having different clinic phenotype with brief literature review.